Artemether + Lumefantrine is a fixed-dose antimalarial combination used for the treatment of uncomplicated Plasmodium falciparum malaria. It contains artemether, a fast-acting artemisinin derivative that rapidly reduces parasite load, and lumefantrine, a longer-acting agent that eliminates residual parasites and helps prevent recrudescence. This dual mechanism ensures high cure rates and reduces the risk of resistance. It is administered orally in a 6-dose regimen over 3 days and is best taken with fatty food to enhance absorption. The combination is widely recommended due to its efficacy, safety, and good tolerability.