Ampicillin-Cloxacillin is a combination antibiotic that contains two penicillin-class drugs: ampicillin and cloxacillin. It is used to treat a wide range of bacterial infections by targeting both gram-positive and some gram-negative bacteria. Ampicillin offers broad-spectrum activity, while cloxacillin is particularly effective against penicillinase-producing staphylococci. This combination is commonly prescribed for respiratory tract infections, skin and soft tissue infections, urinary tract infections, and other susceptible bacterial infections. It is typically available in capsule, suspension, or injectable forms.