Artemether-Lumefantrine is a fixed-dose combination antimalarial medication used to treat uncomplicated Plasmodium falciparum malaria. It contains two active ingredients:

Artemether: a fast-acting artemisinin derivative that rapidly reduces the number of malaria parasites.

Lumefantrine: a longer-acting agent that helps prevent parasite recurrence.

This combination is highly effective and well-tolerated, typically administered over a 3-day course. It is included in the WHO's List of Essential Medicines and is widely used in malaria-endemic regions.