Diclofenac + Cholestyramine is a combination medication that pairs diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), with cholestyramine, a bile acid sequestrant. This formulation is typically designed for delayed or modified release, enhancing the gastrointestinal tolerability of diclofenac while maintaining its anti-inflammatory and analgesic effects. It is primarily used to treat conditions such as rheumatoid arthritis, osteoarthritis, and other inflammatory disorders. Cholestyramine helps reduce gastrointestinal side effects and may modulate the drug’s absorption, offering a more sustained release profile.